Cepharanthine is also known as Stephanine, Cepharanthin. It is an extract of Stephania.Why is he so popular recently? It is found in the latest research that it can effectively inhibit the development of COVID-19.
What is cepharanthine
Cepharanthine, a white blood cell proliferation drug, can promote the proliferation of bone marrow tissue and increase white blood cells. For leukopenia. It can increase leukocytes in peripheral blood. Animal experiments have found that it can significantly prevent leukopenia caused by mitomycin, but does not inhibit the anticancer effect of mitomycin. Its mechanism is to promote the proliferation of bone marrow tissue, resulting in the increase of leukocytes. It is used for agranulocytosis caused by tumor chemotherapy and radiotherapy and leukopenia caused by other reasons.
However, the latest Chinese patent specification shows that the multiple of Cepharanthine inhibiting coronavirus replication at a concentration of 10 μ mol / L is 15393 times. Generally speaking, there are 15393 viruses in the culture well, and only one virus is left after treatment with Cepharanthine. Even after 48 hours, no live virus can be found in the culture. This in vitro test is the result of 2406 clinically approved drugs. This is an amazing result.
According to the current research data, the drug's ability to inhibit novel coronavirus ranks high among all novel coronavirus inhibitors found in humans. American scholars have also previously published papers in science, confirming that the data of Cepharanthine are bright among the 26 drugs they study, and are better than those of redcivir and palovide, which have been approved for listing.
The principle of stephanine against novel coronavirus is that it can bind to the S protein of novel coronavirus and interfere with its invasion to host cells.
This is completely different from the antiviral mechanism of oral drugs on the market. For example, Pfizer's paxlovid inhibits 3CL protease, which can effectively inhibit the replication process of the virus in the human body, probably ensuring that the drug will not fail with the variation of the virus.
On the contrary, the principle of Cepharanthine is basically the same as that of neutralizing antibody of novel coronavirus. The principle of neutralizing antibody in the city is almost based on the combination of S protein of the virus to play a "space occupying" function, so that it cannot bind to ACE2 receptor of human cells.
However, such a mechanism is also easy to fail to the variant of novel coronavirus. Because novel coronavirus mostly mutates in S protein, novel coronavirus has gone through a large number of generations from the original strain to the present Omicron. At the same time, a considerable number of neutralizing antibodies of novel coronavirus have lost their neutralizing activity to the new strain. For example, Junshi / Lilly and gsk/vir products have been stopped by FDA.
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