Oleifera Leaves Extract

Product Introduction

Oleifera leaves extract is the dried leaf extract of olive, a plant of the genus Oleaceae. Its main components include flavonoids, terpenes and their derivatives, aromatic compounds, aliphatic compounds, phenolic acid compounds, etc. Among them, flavonoids, terpenes and their derivatives are the main active ingredients. It has multiple pharmacological effects such as lowering blood pressure, lowering blood sugar, anti-oxidation, anti-thrombosis, antibacterial, antiviral, antimicrobial and anti-cancer, and is widely used in medicines, cosmetics and food supplements.

So far, the main components isolated from olive leaves include flavonoids, terpenes and their derivatives, aromatic compounds, aliphatic compounds, etc., among which flavonoids, terpenes and their derivatives are the main active ingredients. 1. Flavonoid compounds The aglycones of flavonoid components isolated from olive leaves are mainly luteolin, apigenin and cilantroflavin. The sugar chains are mostly composed of 1 to 2 sugars. The common sugars are glucose and rutin. The connection positions are mostly at the 7 and 4' positions of the aglycones. At present, about twenty kinds of flavonoid compounds have been isolated. 2. Terpenes and their derivatives Terpenoid components and their derivatives are widely present in olive leaves. In olive leaves, secoiridoids and terpenes are particularly abundant. (1) Secoiridoids: Secoiridoids are a class of compounds among cyclopentane monoterpene derivatives. They are formed by the cleavage of cyclopentane monoterpene compounds and only account for a small part of secoiridoids. Oleuropein is the most representative compound of the secoiridoid ether terpenoids and an important phenolic secoiridoid glycoside with many pharmacological activities. In addition, oleuropein can be hydrolyzed to obtain free hydroxytyrosol. (2) Triterpenoid compounds: The triterpenoid components contained in olive leaves are mainly pentacyclic triterpenoids, with oleanane type being the most representative, such as oleanolic acid and hawthorn acid. 3. Phenolic acid compounds Phenolic acid compounds are a class of organic acids with phenolic hydroxyl groups. Phenolic acid components include vanillic acid, caffeic acid, chlorogenic acid, gallic acid, cinnamic acid, p-hydroxycinnamic acid, 3,4-dihydroxybenzoic acid and 3-hydroxy-4-methoxybenzoic acid. 4. Aliphatic compounds mainly include 3-hexen-1-ol, nerolidol, nonanal, phenylacetaldehyde, etc.

Product Specification

Product Function & Application

Product Function & Application

1. Antioxidant effect The total polyphenols and individual phenolic compounds in olive leaf extract, such as oleuropein, rutin, and caffeic acid, have a strong scavenging effect on nitrite and DPPH free radicals, and can increase the activity of superoxide dismutase (SOD). Oleuropein is an important antioxidant active ingredient in olive leaves. It has a certain protective effect on oxidative myocardial damage caused by local ischemia and reperfusion. Treating rats with oleuropein can increase the cholesterol lipid in the animal heart. In addition, in the in vitro and in vivo antioxidant activity study of oleuropein, it was found that oleuropein has a significant inhibitory effect on light emission, and is stronger than the commonly used antioxidant Trolox.

2. Antibacterial effect Oleuropein and tyrosol isolated from olive leaves have a wide range of antibacterial activity. Studies have shown that oleuropein and tyrosol have inhibitory effects on 5 ATCC standard strains (Haemophilus influenzae strain ATCC9006, Haemophilus mucosa strain ATCC8176, Vibrio cholerae strain ATCC906, Paratyphoid B strain ATCC6539, and Grapefruit aureus strain ATCC25923) and 44 strains isolated from clinical sites (8 Haemophilus influenzae strains, 6 Haemophilus mucosa strains, 4 Vibrio cholerae strains, 5 penicillin-sensitive strains, 6 penicillin-resistant strains, and 15 Salmonella strains).

3. Hypoglycemic effect Olive leaf extract has significant therapeutic effects in lowering blood sugar and anti-hypertension. Its main active ingredients are oleuropeinoleanolic acid and other secoiridoid compounds. When diabetic rabbits were given oleuropein at a dose of 20 mg/kg, malondialdehyde, blood sugar, and most enzymes and non-enzyme antioxidants were significantly restored to the same level as normal rabbits within 16 weeks. Olive leaf extract can improve the body's sensitivity to insulin and eliminate tissue cell resistance to insulin, but its specific mechanism of lowering blood sugar is still unclear. Both olive leaf alcohol extract and ester extract can reduce the blood sugar level of diabetic model mice, and the effect of ester extract is significantly stronger than that of alcohol extract. The ester extract of olive leaves can counteract the increase of total cholesterol, triglycerides and low-density lipoprotein cholesterol in the serum of diabetic model mice. In addition, studies have found that olive leaf extract can inhibit nerve damage caused by hyperglycemia, relieve thermal hyperalgesia caused by diabetes, and can be used to treat diabetic neuralgia. 4. Effects on the cardiovascular system Effects on the heart Oleuropein in olive leaf extract has a significant protective effect on the heart, mainly manifested as resistance to acute doxorubicin cardiotoxicity and anti-ischemia. Oleuropein can also increase the coronary blood flow of isolated rabbit hearts by 50%, and show anti-arrhythmic and antispasmodic effects. Oleuropein can reduce the blood pressure of Wistar rats with hypertension induced by NG-nitro-L-arginine methyl ester, and the heart rate has no significant change. Oleuropein obtained by hydrolyzing olive leaf extract with phosphoric acid also has a hypotensive effect. Effect on blood vessels Many secoiridoid glycosides (including oleuropein) are strong inhibitors of angiotensin-converting enzyme. Their inhibitory effect comes from the highly reactive 2,3-dihydroxyglutaraldehyde structure. The corresponding aglycones produced by enzyme-catalyzed hydrolysis show similar effects to Oleacein. They have a lasting hypotensive effect on rats, cats and dogs (IC50 is 26μmol/L), can reduce the degree of oxidation of low-density lipoprotein, and prevent the occurrence of coronary heart disease and atherosclerosis; oleuropein has a dilating effect on isolated mouse aorta. In addition, olive leaf extract can well inhibit platelet aggregation, which may be related to its strong antioxidant and H2O2 scavenging ability.

5. Anti-tumor effect Oleuropein is an anti-cancer compound with strong efficacy. It can directly destroy actin microfilaments in cell and non-cell tests, inhibit the proliferation and migration of tumor cell lines in a dose-response manner; it can irreversibly surround cancer cells to prevent their replication, movement and invasion. After 9-12 days of oral administration of oleuropein to mice with spontaneous tumors, the tumors can be completely regressed.

6. Anti-inflammatory effect Olive leaf extract has good anti-inflammatory and analgesic effects. Intragastric administration of OLE100, 250 and 500 mg/kg body weight to the acute inflammation model of rats induced by carrageenan can significantly reduce the swelling of the rat hind feet, increase the pain threshold, and significantly reduce the mRNA expression of inflammatory factors TNF-α and IL-1β.

7. Antiviral effect Olive total flavonoids, oleuropein and other chemical components in olive leaf extract have good antiviral effects. Among them, oleuropein has the most prominent effect, which can effectively inhibit the fusion and integration of viruses such as hemorrhagic septicemia virus (VHSV), HIV-1, and HBV. Olive leaf water extract and alcohol extract are used to fight malaria and other diseases caused by bacteria, fungi, and viruses, such as cold or hot flu; in clinical practice, as medicine, they can inhibit viruses, bacteria, microorganisms and toxins caused by them, improve the regeneration capacity of T lymphocytes, NK cells, phagocytes, etc., and enhance the immunity of cells to viral infections.

8. Other effects Olive leaf extract also has the effects of DNA protection, neuroprotection, enhancing immunity, and regulating the endocrine system. Oleuropein can activate pepsin and inhibit lipase, glycerol dehydrogenase, glycerol triphosphate dehydrogenase, etc. to participate in the metabolism of proteins, carbohydrates and lipids; olive leaf extract can protect the lung damage caused by heroin, and has a certain therapeutic effect on lead-poisoned mice. It can reduce the lipid peroxidation damage in the hippocampus caused by lead poisoning, affect the DNA methylation level of muscle tissue, retinal structure, spleen and thymus cell cycle process, etc., prevent the toxic effects of lead on muscle, retina, spleen and thymus, and improve the renal function of lead-exposed mice; combined with methadone can significantly reduce the E2, FSH, and P levels in the plasma of heroin-dependent rats, increase the PRL and LH levels, and reduce the number of cells with positive expression of ovarian VEGF, and the effect is significantly better than that of the single drug treatment group; repair experimental rabbit articular cartilage damage, etc.

Application:

Used as medicine

In addition to being used for food, olive oil is also widely used for beauty, weight loss, and prevention of cardiovascular diseases. It has a unique effect on preventing and treating digestive system diseases in the elderly and promoting brain and bone development in infants and young children. It also has the function of resisting viral infection and various inflammatory diseases. When making bath products and cosmetics, it is beneficial to skin care, fitness, and delaying aging, and is known as the "oil of beauty". For industrial use, it is a high-grade varnish for textiles and printing and dyeing, and it is also a high-grade lubricant and maintenance oil for electronic instruments.

Deliver & Shipping

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