Natural anti-inflammatory ingredients Escin

Escin is a chemical substance with the molecular formula C55H86O24. It is the sodium salt of saponin obtained from the dried mature seeds of the Horse Chestnut Extract, a freeze-dried sterile preparation of a natural phytomedicine.

Horse Chestnut Extract has anti-tissue edema, reduces vascular permeability and prevents water accumulation in tissues, and quickly eliminates the heavy feeling and pressure caused by local edema. It can be used to treat cold stomach pain, bloating and fullness in the stomach and abdomen, noma and worm pain, malaria, and dysentery. It has significant anti-inflammatory, anti-exudative and anti-swelling effects, restores the normal permeability of capillaries, increases venous tone and improves microcirculation. In Europe, its indications are mainly edema due to peripheral circulatory disorders, mainly in oral and topical dosage forms. Escin is internationally recognized as an important natural drug. After long-term clinical observation of thousands of cases, it is believed that hesperidin sodium has a high therapeutic value for trauma and peripheral vascular diseases.

Escin extract is the sodium salt of saponin obtained from the dried mature seeds of the hepatica plant, Tenebrium, in a freeze-dried sterile preparation, and is an internationally recognized important natural botanical. With soothing, anti-inflammatory and calming properties, escin improves skin protection and reduces the occurrence of sensitive skin, it is also often used in topical medicines and cosmetics, and is a best-selling herb in Europe.

The extraction of Escin was carried out according to method 1, 100 g of haplodendron was ground, and then 300 mL of each of 60% alcohol was extracted in 3 times, extracted and filtered, and 800 mL of extract was obtained, and the extract was heated and concentrated on a constant temperature water bath at 60°C for 48 h, and 78 mL of concentrate was obtained, and then extracted with ethyl acetate 3 times, and 1200 mL of supernatant was obtained, and 26.7 mL of precipitated mucilage was obtained, and the supernatant was water-bath The supernatant was concentrated to obtain 12g of precipitate, which was used as raw material for purification experiments.
This extraction method is first extracted with alcohol, the extracts are adsorbed with activated carbon to remove the pigment, heated and concentrated, the fat-soluble substances are removed with ethyl acetate, and the extracts are combined and concentrated, then the precipitate is obtained after dissolution by methanol and precipitation by acetone.
Removal of pigment by activated charcoal:This reduces the pigment in the extract and makes the color of the extract as low as possible.

n-butanol concentrate precipitated by acetone: because saponin is insoluble in ether, acetone and other solvents, so the crude saponin first dissolved in a small amount of methanol, then add three times the amount of acetone drop by drop, shake well, saponin that precipitates, put in the refrigerator frozen overnight, centrifugation, you can get a slightly pure crude product, in this operation to pay attention to the precipitation to be adequate, otherwise the loss of saponin more.

Escin is a mixture of more than thirty saponins obtained from Safflower seeds. Due to the different extraction methods, the content of the saponins obtained varies.

The Chinese herb horse chestnut extract escin is the main active ingredient of the horse chestnut extract extract, which has anti-inflammatory, anti-exudative, restores capillary permeability, improves venous tone, improves blood circulation and promotes brain cell recovery.

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