Bacopa Monnieri Extract

Product Introduction

Bacopa monnieri (scientific name: Portulaca oleracea L.) is a common herb that is widely distributed around the world. The herbal parts of Bacopa monnieri are used medicinally or edible and are widely used in many traditional medicines. Among them, bioactive compounds extracted from Bacopa monnieri are one of the current research hotspots. This article will discuss the efficacy of Bacopa monnieri extract from three aspects: its chemical composition, pharmacological effects and clinical effects.

The main chemical components of Bacopa monnieri include a variety of biologically active substances, such as phytic acid, flavonoids (such as apigenin, apigenin, etc.), organic acids, alkaloids, monoterpenes, terpenoids, and triterpenoids sterols, polysaccharides and vitamins, etc. These compounds play an important role in the effects of Bacopa monnieri extract.

Product Specification

Product Function & Application

1. Pharmacological activity on nerves

(1) Beneficial effects on learning and memory. Research shows that Bacopa monnieri and its extracts have brain-building effects. Bacopa monnieri and its ethanol extract can significantly improve the learning ability of rats. The effect of promoting cognitive function is mainly due to the two active saponins of Bacopa monnieri saponin A and B in the ethanol extract. In addition to promoting the learning and memory functions of normal rats, the active ingredients can also inhibit amnesia (memory loss) caused by scopolamine, electroshock and restraint stress.

(2) Anti-anxiety effect Bacopa monnieri extract is different from benzodiazepine anti-anxiety drugs. The former can improve cognitive function while producing anti-anxiety effects, while the latter has the side effect of causing dementia. A rat anti-anxiety experimental model (elevated plus maze model) was used to conduct a comparative study on the anti-anxiety effects of BM standard extract and benzodiazepines. Rats were orally administered 5, 10 and 20 mg/kg BM extract and intraperitoneally injected Lorazepam (LZP) 0.5mg/kg. Compared with lorazepam, high-dose Bacopa monnieri extract has a stronger anti-anxiety effect and is significantly better than LZP. Bacopa monnieri not only does not cause dementia, On the contrary, it can enhance the memory function of demented animals and people.

(3) Antidepressant effect: The methanol standard extract of Bacopa monnieri has a strong antidepressant effect on rodent depression models. Compared with the antidepressant imipramine (15mg/kg), it has better effects on forced swimming and acquired helpless depression. In the model, 20 or 40 mg/kg of Bacopa monnieri was given once a day for 5 days, which can produce obvious antidepressant effects.

(4) The anticonvulsant effect of Bacopa monnieri was used alone or in combination with phenytoin (an anticonvulsant drug that causes cognitive dysfunction), and was evaluated using the mouse passive avoidance test, the maximum number of electroshock epileptic seizures, and motor function. The results show that , Phenytoin can damage cognitive function, while Bacopa monnieri can reverse the damage of phenytoin on cognitive function, significantly improve memory acquisition and memory retention Chemicalbook, but does not affect the anticonvulsant effect of phenytoin; Bacopa monnieri can be used alone or in combination with other The combined use of anti-epileptic drugs has also confirmed that Bacopa monnieri has a strong anti-epileptic effect and can correct the damage to cognitive function caused by anti-epileptic drugs.

2. Anti-tumor effect: Bacopa monnieri extract can inhibit the growth of tumor cells at low concentrations; the toxicity at high concentrations still needs further in vivo experiments to clarify. The drug may work by inhibiting DNA replication.

3. Liver protection studies have shown that Bacopa monnieri prevents the inhibition of antioxidant enzymes and the reduction of glutathione levels, and inhibits the increase in peroxidized lipids after morphine administration, thereby producing liver protection against morphine-induced liver poisoning in rats. effect.

4. Relax smooth muscle Bacopa monnieri ethanol extract has a relaxing effect on all isolated tissues such as rabbit and guinea pig isolated trachea, pulmonary artery and aorta, and can reduce the contraction of guinea pig tracheal strips caused by histamine in a dose-dependent manner. Among them, the most obvious effect was on guinea pigs, but the tracheal specimens were completely relaxed. The relaxing effect of the extract on blood vessels could not be blocked by atropine and pracerolol, but the relaxing effect of the extract on tracheal specimens could be partially blocked by pracerolol. Indomethacin can block the tissue relaxation caused by plant extracts, and the plant extracts have the same relaxing effect on blood vessels with or without endothelium. The results suggest that the relaxation caused by Bacopa may involve prostacyclin compounds and β-adrenergic receptors. In addition, this relaxation does not depend on the activation of endothelial and muscarinic receptors.

5. Other effects In addition to the psychoactive effects, the anti-inflammatory, cardiac and other pharmacological effects of Bacopa monnieri preparations or extracts were also evaluated. The inhibitory effect of Bacopa monnieri on experimental inflammation was compared with the anti-inflammatory drug indomethacin. The results showed that BM effectively inhibited the experimental inflammatory response by inhibiting prostaglandin synthesis and partially stabilizing the lysosomal membrane. And at anti-inflammatory doses, Bacopa does not cause gastrointestinal irritation. Bacopa monnieri extract can heal different types of inflammation.

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